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Advanced therapy with mesenchymal stem cells

Individually designed cell therapy to support tissue regeneration and the regulation of inflammatory processes.
It is carried out exclusively on the basis of expert clinical judgment.

It is intended for patients with selected conditions for whom standard therapeutic approaches do not provide satisfactory clinical outcomes or are associated with greater clinical, financial, and organizational burden.

MSC therapies do not replace standard treatment and are performed exclusively on the basis of individual medical judgment.
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What are mesenchymal stem cells?

Mesenchymal stem cells (MSCs) are a special type of adult, undifferentiated cells that have the ability to adapt to the needs of their environment and support the body’s natural regenerative processes.

Today, they are used in advanced therapeutic approaches primarily because they can simultaneously regulate inflammation, influence immune responses, and promote the regeneration of damaged tissues. Their key advantage lies in the fact that they do not act only locally on symptoms, but contribute to improving the conditions in which tissues can regenerate more effectively.

MSC therapy is always individually tailored and based on expert clinical judgment, as its effectiveness depends on correct indication and a comprehensive understanding of the patient’s overall health condition.

Technology and how it works?

Mesenchymal stem cells (MSCs) are adult, undifferentiated cells that can be obtained from various tissues, such as bone marrow, adipose tissue, and others. Their key characteristic is their ability to respond to the environment in which they are introduced and, through their biological signals, support healing and regenerative processes.

It is important to understand that MSCs do not create new organs and do not directly replace damaged tissue. Their role is not to “build new tissue,” but to create favorable conditions in which the body can begin to regenerate more effectively on its own.

The main mechanism of MSCs is so-called paracrine activity. This means that the cells release biologically active substances that affect surrounding cells: they regulate excessive inflammatory responses, support immune system function, promote the formation of new blood vessels, and reduce scarring and cell death. In this way, MSCs help restore balance in tissue that has been disrupted by disease or injury.

MSCs are not embryonic stem cells derived from embryos. They are adult cells that do not interfere with early organism development and do not raise the ethical concerns associated with embryonic sources. Because of their safety, adaptability, and broad range of biological effects, MSCs are today among the most commonly used cellular therapies in clinical practice.

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The MSC therapy process: steps toward health

Mesenchymal stem cell (MSC) therapy follows a clear and structured sequence of steps, from the initial consultation to post-therapy follow-up.

* Autologous – your own stem cells are used, collected through a minimally invasive procedure, prepared under sterile conditions, and then applied to the target area or systemically.
* Allogeneic – carefully selected and prepared donor stem cells are used when this approach is deemed clinically more appropriate.

 

1.

Submit inquiry

The first step is submitting an inquiry through the website.

2.

Phone calls and guidance

We will contact you shortly, verify basic information, and, if necessary, refer you for a consultation with a physician.

3.

Medical assessment

The physician conducts a clinical examination, reviews your medical records, and determines whether MSC therapy is suitable for your condition. Any potential contraindications are identified, and the most appropriate therapeutic approach is defined.

4.

Arrangement and administration of MSC therapy

If the assessment is positive, MSC therapy is scheduled, which can be autologous or allogeneic *. The procedure is generally well tolerated, does not require hospitalization, and allows a quick return to daily activities.

5.

Post-therapy follow-up

After the therapy, your well-being and response to treatment are monitored, with additional check-ups or adjustments made if necessary.
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Submit inquiry

The first step is submitting an inquiry through the website.

Phone calls and guidance

We will contact you shortly, verify basic information, and, if necessary, refer you for a consultation with a physician.

Medical assessment

The physician conducts a clinical examination, reviews your medical records, and determines whether MSC therapy is suitable for your condition. Any potential contraindications are identified, and the most appropriate therapeutic approach is defined.

Arrangement and administration of MSC therapy

If the assessment is positive, MSC therapy is scheduled, which can be autologous or allogeneic *. The procedure is generally well tolerated, does not require hospitalization, and allows a quick return to daily activities.

Post-therapy follow-up

After the therapy, your well-being and response to treatment are monitored, with additional check-ups or adjustments made if necessary.

Most commonly used 
therapeutic areas for MSC

Mesenchymal stem cell (MSC) therapy is primarily used today for conditions where chronic inflammation, degeneration, or recurring injuries impede the body’s natural regeneration. MSCs provide the strongest supportive role in orthopedics, systemic treatment of chronic inflammation, and oncology.

1. Orthopedics

The most common and clinically established uses
     · wear and tear of the knee and hip joints
     · injuries to cartilage, ligaments, and tendons
     · sports injuries
     · selected degenerative spinal conditions

Goal: reduce inflammation, relieve pain, improve mobility, and support tissue regeneration.

2. Systemic treatment of chronic inflammation

When the disease affects more than one site
     · inflammatory rheumatic diseases
     · selected autoimmune conditions
     · chronic inflammatory gastrointestinal conditions

Goal: regulate the immune response and reduce pathological inflammation in the body.

The therapy is intended for patients for whom it has been deemed appropriate after a thorough clinical assessment.

3. Other

Other areas where MSCs are used or being researched:
     · Chronic wounds – wounds that are difficult to heal, impaired healing
     · Vascular diseases – selected conditions with impaired microcirculation
     · Dermatology – supportive skin regeneration
     · Maxillofacial and oral surgery – tissue regeneration after procedures

Oncology

Hematologic oncology – informational area

MSCs are not a therapy for treating cancer. In hematologic oncology, they are used exclusively in supportive or research contexts (e.g., immune response modulation, support after aggressive therapies) and always within the framework of strict clinical assessment.

The therapy is suitable only for selected patients and is always performed following a thorough clinical assessment.

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Cell count and estimated therapy costs

In mesenchymal stem cell (MSC) therapy, there is no single dose that is suitable for all patients. The final number of cells and the method of administration are always determined by the physician based on the clinical picture, indication, and the individual response of the patient.

Orthopedics

Approximate number of cells: approximately 5 million MSC

Indicative price: approximately €1,900 per joint

Smaller joints (osteoarthritis, rheumatoid arthritis)

Approximate number of cells: approximately 0.2 million MSC

Indicative price: approximately 180 €

Systemic use (chronic inflammatory conditions)

Approximate number of cells: approximately 100 million MSCs

Estimated price: submit an inquiry

Chronic wounds and local applications

Approximate number of cells: approximately 5 million MSCs per cm² of wound

Estimated price: submit an inquiry

Other therapeutic areas

The number of cells and costs are determined individually based on the indication and therapeutic plan.

The values provided represent approximate ranges and do not guarantee efficacy or a standardized therapeutic dose. MSC therapy is performed exclusively based on individual medical assessment and is not a substitute for standard treatment. The final decision regarding therapy, cell count, and cost is made after clinical evaluation.

MSC therapy does not replace standard treatment but may, in certain cases, be used as an alternative or complementary therapeutic approach for individuals for whom standard treatment is not feasible, suitable, or has not achieved the desired outcome.

Submit an inquiry for MSC therapy

Submit an inquiry for MSC therapy and register for treatment. Our team will support you on your journey toward recovery and improved well-being.

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Frequently asked questions

GENERAL

What exactly are stem cells?

Stem cells are a special type of cell with two key properties: they can divide and, under certain conditions, develop into more specialized cells. They are also important for intercellular communication, as they can release signaling molecules that influence the activity of surrounding cells and tissues.

In modern medicine, cellular approaches are used within clearly defined and regulated procedures. It is crucial to consider the type of cells used, their origin, preparation method, and the indication for which they are applied. Different types of cell therapies vary in their function, purpose, and method of use.

It is also important to understand that the term “stem cells” is often interpreted differently by the public. In medicine, it does not refer to a single “universal therapy,” but rather to a broad range of approaches whose use must always be professionally justified and supervised by a physician.

What does it mean for something to be an ATMP?

ATMPs (Advanced Therapy Medicinal Products) are advanced medicines for humans based on genes, tissues, or cells. These include, for example, somatic cell therapies, tissue engineering, and gene therapies.

For patients, this primarily means that such products must meet strict requirements for quality, safety, traceability, documentation, and conditions of use. The purpose of the ATMP framework is to ensure that procedures are clear, controlled, and aimed at safe clinical application.

What is the difference between “cell therapies” and “stem cells” as marketing terms?

In practice, the term “stem cells” is sometimes used very broadly, which can give people the impression that it refers to a single method suitable for almost anyone. In a professional context, however, the reality is different: the product must be precisely defined, correctly classified, prepared in a standardized way, and used within the appropriate clinical context.

For this reason, the term “cell therapy” or “cell/tissue products” is more commonly used in medicine, as it is more precise and less misleading. Many of these products fall under ATMPs (advanced therapy medicinal products) according to regulations, which entails a higher level of oversight and clear rules regarding quality and safety.

Are all “cells from fat / umbilical cord / placenta” automatically stem cells?

Not necessarily. These biological sources can contain different types of cells and are often mixtures. What matters is which cells are actually present, their composition, how the material is processed, how it is verified, and whether it is used in accordance with regulations and clinical protocols.

For this reason, responsible practice always requires a medical consultation and clear documentation to ensure professional assessment and safe handling.

Why are there so many warnings about “unauthorized” stem cells?

Because a global market has emerged where cellular interventions are often promoted very broadly, sometimes without sufficient evidence or proper oversight. Regulators and professional associations, therefore, emphasize that use must occur within approved frameworks, where procedures are standardized, and responsibilities are clearly defined.

These warnings are not meant to discourage patients from medicine but to help distinguish serious, controlled approaches from offers that may overpromise and lack transparency.

Can you tell me if this menu will help me?

The most correct and also the most useful approach for you is to have a physician make this decision after a consultation. In cell therapies, suitability strongly depends on the diagnosis, stage of the disease, previous treatments, overall health, and your personal goals.

Our role as a manufacturer is to ensure that the cell product is high-quality, traceable, and prepared according to standards. Whether a particular therapy is appropriate for you, and what the realistic expectations are, can be best determined by a physician at the clinic.

What does “traceability” mean in the context of cell products?

Traceability means that the entire flow of the material is documented and controlled: from the source, processing, and testing to storage and delivery to the clinic.

For the patient, this is important because traceability ensures transparency, consistency, and a higher standard of safety—you always know what was used, how it was prepared, and under what conditions.

Why do some providers offer “stem cells” for almost anything (knees, autism, rejuvenation…)?

Because the term sounds convincing, and people are often looking for new options. The problem is that a “one therapy for all” approach is rarely realistic in medicine.

Serious medical practice is based on selecting therapy according to the diagnosis, disease mechanism, and supporting evidence, so universal promises are usually a sign to be cautious and ask for clear explanations and documentation.

Is “minimally manipulated” important?

Yes. The level of processing is important because it affects how the product is regulated and what standards apply for preparation, quality control, and use.

In practice, this means that the more standardized and properly classified the process is, the clearer the rules and responsibilities are—providing the patient with greater predictability and a stronger safety framework.

Can stem cells cause cancer?

No. Cell therapies used in regulated and professionally supervised medicine are not tumorigenic.

In biology, we rarely speak of an absolute zero risk, but for clinically applied cell-based approaches, the risk of cancer development is extremely low and not expected in practice. That is why the cell types used are precisely defined, prepared according to standardized procedures, and applied for clearly defined indications.

For the patient, this means that in properly supervised medical treatment, a safety-first approach is used, and tumorigenicity is not a clinically relevant concern.

Is “rejuvenation” with stem cells proven?

In medical terms, cell therapies are considered within clearly defined indications, where benefits and risks are carefully evaluated. Claims about “rejuvenation” are common in the public sphere, but professionals generally do not treat them as a standard medical indication.

If someone promises “rejuvenation” as a guaranteed effect, it is wise to ask for evidence, protocols, and the regulatory framework.

Why is it essential that the clinic, and not the company, decides on the indication?

Because the indication is a medical decision that requires professional assessment, responsibility for treatment, and patient monitoring. The physician is the one who can comprehensively evaluate your condition, explain the options, and choose the most appropriate treatment path.

The company can ensure product quality, but cannot replace the clinical judgment that is central to safe medical practice.

What are the typical risks of improperly regulated cell procedures?

As with any medical procedure, there are potential risks, which is why proper execution and oversight are crucial. In inadequately controlled procedures, the literature reports complications such as infections, immune reactions, or unwanted local responses. In some unverified approaches, more serious complications have also been described, which is a key reason why the medical community insists on regulated procedures.

The most important message for patients is that when the process is conducted in a standardized and professional manner, the safety framework is significantly stronger—making the choice of an appropriate clinic and correct pathway essential.

How does your company contribute to safety if the clinic performs the administration?

We contribute to safety by ensuring strict quality control, traceability, and oversight of the manufacturing processes in accordance with applicable standards. This includes documentation, checks, and procedures that provide transparency from the source to delivery to the clinic.

The clinic, on the other hand, is responsible for the medical aspects: determining the indication, the method of administration, monitoring, post-procedure instructions, and managing any potential complications. This division is common and sensible, as each part of the process requires different expertise and responsibility.

Are there “approved” stem cells in medicine?

Yes, the most well-known example of stem cell therapy is the use of hematopoietic stem cells, which are utilized for certain blood disorders and have become part of established medical practice.

In addition, the development of many other cell therapies is ongoing. These therapies are being studied within regulated frameworks and are gradually evaluated for their safety and effectiveness.

For patients, each therapy must be assessed based on the specific medical condition it addresses and the supporting evidence, rather than simply relying on whether it is labeled as a "stem cell" therapy.

How can a patient recognize “red flags”?

Red flags are situations where there is insufficient clarity or professional transparency, for example:
• promises of “guaranteed success” or “works for everyone”
• no clear diagnosis or indication
• no explanation of the procedure, limitations, or realistic expectations
• unclear origin or description of the cells
• no documentation of the procedure
• pressure to pay or decide quickly

In good practice, patients should receive clear information, time to consider their options, and the opportunity to ask questions.

What does “clinical study” mean in this context?

A clinical study is a controlled research framework in which safety and efficacy are systematically evaluated according to a predetermined protocol, under the oversight of ethics committees and regulators.

For the patient, this means that the approach is tested in a way that allows for more reliable conclusions and better comparison with existing treatment options.

Are infections a real risk?

Infections are a potential risk with any procedure that involves introducing material into the body, which is why aseptic techniques, testing, and clinical protocols are standard parts of safe practice.

In properly managed procedures, it is precisely this system of controls that significantly reduces the risks.

What does a patient usually need for the first consultation at the clinic?

It usually helps if you have prepared:
• a brief description of your issues (when they started, what worsens or eases them)
• any existing diagnosis
• test results (e.g., MRI, X-ray, laboratory tests)
• a list of previous treatments and their effects
• a list of medications, allergies, and significant medical conditions

The clinic will typically provide a precise list tailored to your case, so it’s best to follow their instructions.

What is the “right next step” if I am interested in the therapy?

The right next step is a professional consultation at the clinic. There, the physician assesses whether the approach is suitable for you, explains realistic expectations, the procedure, possible risks, and alternatives, and proposes a further plan.

This is the safest and most sensible way to get a clear, individually tailored answer—without guesswork or uncertainty.
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ORTHOPEDICS / KNEES / PAIN

Are cell therapies used for knee pain?

Yes. In modern orthopedics, cell therapies are being researched and, in certain clinical settings, used for knee pain—mainly in connection with degenerative changes, chronic inflammatory conditions, and specific soft tissue injuries.

It is important to emphasize that this is not a universal solution for all types of pain, but an approach that may be suitable only for certain patients with a clearly defined indication. Suitability is always determined by an orthopedic specialist after a comprehensive assessment.

How is cell therapy supposed to work for the knee?

Scientific literature describes that certain cell populations primarily have a paracrine effect. This means they release signaling molecules that can influence inflammatory processes, cellular communication, and the joint environment.

This mechanism is different from directly “repairing” or replacing damaged tissue and is far more complex than it is often simplistically presented in the public.

Is this a treatment for knee osteoarthritis?

In some cases, cell therapies are considered a complementary option for knee osteoarthritis, especially in early to moderate stages of the disease. They are not a replacement for standard orthopedic approaches such as physiotherapy, lifestyle adjustments, medications, or surgical procedures.

The physician determines whether cell therapy can contribute to symptom management or improve joint function in a specific case.

Does cartilage regenerate?

Complete regeneration of joint cartilage in adults is biologically very limited. Current scientific evidence does not support claims of reliable “new cartilage” formation following cell therapies.

The realistic goals of the therapy are therefore primarily focused on symptom relief, improved mobility, and quality of life, rather than promises of complete anatomical restoration of the joint.

Does this mean I can avoid knee surgery?

This cannot be predicted in advance. In certain cases, physicians may consider cell therapies as part of a conservative approach before surgery or as a supportive option alongside other treatments.

However, surgical indications are based on clearly defined clinical criteria and remain entirely within the domain of the orthopedic specialist.

Does it also help with sports-related knee injuries?

In scientific literature, cell therapies are also mentioned in the context of soft tissue injuries, such as ligaments, meniscus, or tendons. However, acute injuries, chronic changes, and postoperative conditions are treated differently.

Therefore, there is no single answer—the decision depends on the type of injury, the time since its occurrence, and a comprehensive clinical assessment.

How long do the effects last?

The duration of any potential effects varies widely and depends on the indication, the method used, the individual’s biological response, and accompanying measures (e.g., rehabilitation).

Different outcomes are reported in the literature, so you should always discuss realistic expectations with your physician.

Are the results immediate?

No. If improvement occurs, it is usually gradual. Cell-based approaches work through biological processes that take time and are not comparable to the immediate effect of painkillers or anti-inflammatory injections.

What is the difference between cell therapy and PRP?

PRP (platelet-rich plasma) is based on platelets and growth factors derived from your own blood. Cell therapies, on the other hand, involve cell populations with different biological properties.

The choice of method depends on the indication and clinical assessment.

Can pain worsen?

After the procedure, temporary inflammation or increased discomfort may occur, which is part of the biological response.
The physician should inform you in advance about possible courses and how they will be monitored.

Do I need to have an MRI or X-ray before the therapy?

Often, yes. Imaging diagnostics allow for an accurate assessment of joint structure and are an important part of determining the suitability of the therapy.

Why does the therapy help some people more than others?

Because there is significant biological variability. The response depends on the stage of the disease, lifestyle, body weight, activity level, and many other factors.

Is the therapy suitable for “worn-out knees”?

Suitability depends on numerous factors, such as the degree of wear, joint alignment, stability, body weight, age, physical activity, and overall health.

In advanced osteoarthritis, different therapeutic approaches are often required, which the physician will clearly explain during the consultation.

Is the therapy painful?

The sensation during and after the procedure is individual. The method of administration, use of local anesthesia, and any short-term discomfort are part of the medical protocol, which the physician explains to the patient.

Most patients describe the procedure as manageable, though experiences may vary.

Is it a one-time procedure?

In some protocols, it is a single application, while in others, follow-up or repetition is planned.
The decision is based on clinical judgment and the individual patient’s response.

Can cell therapy replace corticosteroid injections?

Cell therapies are not a direct replacement for corticosteroids. They are different therapeutic approaches with distinct mechanisms of action.

The physician determines which approach is appropriate based on joint condition, symptoms, and treatment goals.

Are cell therapies “natural”?

They are biological approaches, but this does not mean they are risk-free or suitable for everyone. As with all medical procedures, professional assessment and oversight are essential.

Is the therapy suitable for older adults?

Age alone is not an exclusion criterion. More important factors are overall health, mobility, comorbidities, and the patient’s realistic expectations.

Can I continue with my regular physiotherapy?

In many cases, physiotherapy is an important part of a comprehensive approach. The physician determines the rehabilitation plan and timeline.

What is the realistic goal of cell therapy for the knee?

The realistic goals are pain reduction, improved joint function, and enhanced quality of life. Cell therapies are not a miracle cure but part of a professionally guided therapeutic process.
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Legal and regulatory aspects of stem cell use and production

Mesenchymal stem cell (MSC) therapies are considered an advanced form of modern medicine and are therefore subject to strict regulation in the European Union, with the primary goal of ensuring patient safety. Read more about the legal and regulatory framework for the use and production of stem cells.

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