Mezenhimske matične celice (MSC) se uveljavljajo kot obetavna terapevtska možnost pri vnetnih revmatičnih in avtoimunskih boleznih, saj združujejo imunomodulatorne, protivnetne in regenerativne lastnosti z na splošno ugodnim varnostnim profilom.
Velike nedavne meta-analize randomiziranih kontroliranih študij, ki vključujejo več kot 2.000 bolnikov, kažejo, da presaditev mezenhimskih matičnih celic (MSC) lahko bistveno zmanjša bolečino in izboljša funkcijo sklepov pri osteoartritisu. Pomenljive izboljšave so bile poročane v ocenah VAS in WOMAC po intraartikularnih injekcijah celic iz kostnega mozga, maščobnega tkiva ali popkovnične vrvice, pri čemer se pojavnost neželenih učinkov ni povečala v primerjavi s kontrolami (Zeng et al., 2025; Zeng et al., 2024; Tian et al., 2024; Cao et al., 2025).
Pri sistemskih avtoimunskih boleznih so mezenhimske matične celice (MSC) pokazale sposobnost:
Te koristi so bile ponovno opažene brez jasnih znakov povečane resne toksičnosti (Zeng et al., 2025; Mesa et al., 2023; Zeng et al., 2022; Zhou et al., 2020).
Pri revmatoidnem artritisu sistematični pregledi in meta-analize opisujejo terapijo z MSC kot varno in dobro prenašano, z zaznanimi trendi zmanjšanja vnetja, izboljšanja funkcionalnih kazalnikov in laboratorijskih parametrov. Vendar so koristi pogosto zmerne in lahko po 6–12 mesecih brez ponovitve zdravljenja oslabijo (Mesa idr., 2023; Zeng idr., 2022; Hwang idr., 2021; Karamini idr., 2020).
Pri revmatičnih stanjih trenutne študije dajejo prednost:
Pomembni izzivi ostajajo:
Na splošno trenutni dokazi podpirajo uporabo MSC kot relativno varnega in eksperimentalno učinkovitega dodatka pri izbranih refraktarnih vnetnih revmatičnih boleznih. Najbolje se jih uporablja znotraj kontroliranih kliničnih študij, dokler niso bolj jasno določeni standardizirani protokoli ter dolgoročna učinkovitost in varnost (Zeng et al., 2025; Hetta et al., 2025; Mesa et al., 2023; Zeng et al., 2024; Jasim et al., 2022; Zaripova et al., 2023; Feng et al., 2025; Munir & McGettrick, 2015; Sarsenova et al., 2021).
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