Critical limb ischemia represents the worst stage of peripheral arterial disease, when the blood supply to the limb becomes so poor that it can lead to limb loss. Traditionally, surgical procedures are often performed for such serious conditions, but many patients are not suitable candidates for such operations due to various health reasons. Until recently, the only option for these patients was amputation.
Today there is hope in the form of cell therapies that use mesenchymal stem or stromal cells (MSCs). These cells are exceptional for their ability to accelerate the development of new capillaries, which allows improvement of limb perfusion. This not only reduces the risk of amputation but also significantly improves the quality of life of patients.
With the use of MSC cell therapy, your options can drastically change. The therapy can stimulate the growth of new blood vessels and you can start to feel improvement, enabling your leg to be preserved and your mobility to improve.
MSC are multipotent cells that can differentiate into mesodermal cell lineages, such as adipocytes, osteocytes, and chondrocytes. MSC were initially isolated from bone marrow, but it is now known that they are found in almost all tissues (e.g., adipose tissue, umbilical cord, etc.). MSC have the ability to migrate to the site of injury in the body, where they can differentiate and replace damaged cells, as well as promote tissue regeneration. Additionally, they have the capacity for paracrine signaling and cell-to-cell communication by secreting various soluble factors and extracellular vesicles. In an inflammatory environment, they act immunomodulatory on different cells of the innate and adaptive immune systems, which is one of their main properties exploited for therapeutic purposes.
They can be used for local tissue regeneration or for their systemic effects.
It is important to know that PRP treatment is not the same as our therapy. PRP treatment uses only 1 to 3 stem cells, while our therapy uses a dosed amount of 15 to 20 million stem cells.
We at GaiaCell are a biotechnology company specialized in safe and effective cell therapies in orthopedics, hematooncology, pulmonology and other therapeutic areas. Our high-tech laboratories with GMP certificate and research center guarantee the highest quality and innovation. We also offer contract development and manufacturing (CDMO), ensuring top-notch project execution.