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In Hemato-Oncology, stem cell transplants are often used as an important step in the fight against serious diseases. It is a procedure where healthy cells are transferred into the body of a patient who urgently needs them. However, complications can sometimes occur.
In certain cases, the transplanted cells, instead of helping, begin to attack the patient's body. This phenomenon is known as GvHD (Graft-versus-Host Disease), which occurs in approximately 30-40% of cases if the cell donor is a perfect match, and in 60-80% of cases if the donor is not a perfect match. This disease presents a challenge, as the transplanted cells begin to aggressively attack vital organs. It's as if our body has mistaken a friend for an enemy - cells that should help become aggressors.
As a result, serious inflammatory processes and tissue damage can occur, which can lead to serious health complications. In cases where the body does not respond to standard treatment with steroids and biological drugs, the mortality rate increases and reaches around 85%.
At GaiaCell, we have developed special preparations that contain mesenchymal stem cells. These cells are special because they have the ability to calm the immune system and restore damaged tissue. This means that they can help treat this disease, which is a big step in the world of medicine.
MSC are multipotent cells that can differentiate into mesodermal cell lineages, such as adipocytes, osteocytes, and chondrocytes. MSC were initially isolated from bone marrow, but it is now known that they are found in almost all tissues (e.g., adipose tissue, umbilical cord, etc.). MSC have the ability to migrate to the site of injury in the body, where they can differentiate and replace damaged cells, as well as promote tissue regeneration. Additionally, they have the capacity for paracrine signaling and cell-to-cell communication by secreting various soluble factors and extracellular vesicles. In an inflammatory environment, they act immunomodulatory on different cells of the innate and adaptive immune systems, which is one of their main properties exploited for therapeutic purposes.
They can be used for local tissue regeneration or for their systemic effects.
It is important to know that PRP treatment is not the same as our therapy. PRP treatment uses only 1 to 3 stem cells, while our therapy uses a dosed amount of 15 to 20 million stem cells.
We at GaiaCell are a biotechnology company specialized in safe and effective cell therapies in orthopedics, hematooncology, pulmonology and other therapeutic areas. Our high-tech laboratories with GMP certificate and research center guarantee the highest quality and innovation. We also offer contract development and manufacturing (CDMO), ensuring top-notch project execution.